Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging.

Sainan Zhang, Bichun Guo, Junshun Fang, Shanshan Wang, Yicen Liu, Die Wu, Nannan Kang, Yang Zhang, Xin Zhen, Guijun Yan, Lijun Ding, Haixiang Sun, Chuanming Liu

Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China.Center for Reproductive Medicine and Obstetrics and Gynecology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China. · pubmed

Paper

Abstract

Ovarian aging-induced decline in oocyte quality has been a main issue in women of advanced maternal age. However, the potential mechanism remains elusive, and there are no effective strategies to ameliorate aged oocyte quality. The lipid metabolism of oocytes has drawn great attention, but the intrinsic regulation of oocyte quality by metabolites, metabolic enzymes, and intracellular mediators is less well-characterized.

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Research summary

Abnormal cholesterol-cholesteryl ester metabolism negatively affects oocyte quality during ovarian aging. This research addresses a potential mechanism underlying the decline in oocyte quality with age, which is a critical aspect of reproductive aging and longevity.

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