Distinct responses to non-autonomous UPR

Aeowynn J Coakley, Adam J Hruby, Jing Wang, Andrew Bong, Tripti Nair, Carmen M Ramos, Athena Alcala, Daniel Hicks, Maxim Averbukh, Naibedya Dutta, Darius Moaddeli, Camilla Pearson, Cynthia J Siebrand, Mattias de Los Rios Rogers, Arushi Sahay, Sean P Curran, Peter J Mullen, Bérénice A Benayoun, Gilberto Garcia, Ryo Higuchi-Sanabria

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA. · pubmed

Paper

Abstract

The capacity to deal with stress declines during the aging process, and preservation of cellular stress responses is critical to healthy aging. The unfolded protein response of the endoplasmic reticulum (UPR

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that distinct responses to non-autonomous unfolded protein response (UPR) can influence cellular stress management during aging. This research is relevant as it addresses the preservation of cellular stress responses, which is critical for healthy aging and potentially targets the underlying mechanisms of aging rather than merely treating age-related symptoms.

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