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RESEARCH PAPER / 2025-11-24

What Characterizes the Exceptional Cognition of Superagers? A Systematic Review of Multidomain Biomarkers of Successful Cognitive Aging.

Yiru Yang, Xiaolei Li, Shudan Gao, Yuanxu Gao

School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012China. · pubmed

Abstract

Substantial heterogeneity in cognitive aging trajectories has been observed among older adults, with some individuals maintaining exceptional cognitive function ("superagers" or "successful cognitive aging (SCA)"). The biological mechanisms underlying SCA remain unclear. This systematic review synthesizes current evidence on quantifiable SCA biomarkers to address this critical gap.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to synthesize current evidence on quantifiable biomarkers associated with successful cognitive aging. This research is relevant as it explores biological mechanisms that could contribute to understanding and potentially mitigating aspects of cognitive decline associated with aging.

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