L-Quebrachitol from Sea Buckthorn Leaves Extends Lifespan by Regulating Antioxidant Activity and Autophagy through AMP-Activated Protein Kinase/SIR-2.1/DAF-16 and IIS Signaling Pathways.

Jinmei Zhao, Juan Wei, Yumei Jiang, Jörg Thomas Mörsel, Yury A Zubarev, Yang Bi

College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China.College of Food Science and Engineering, Gansu Agricultural University, Lanzhou 730070, China. · pubmed

Paper

Abstract

L-Quebrachitol (QBC), a derivative of L-inositol, exhibits antioxidant and antimetabolic disorder properties; however, its antiaging effects remain unexplored. This study isolated QBC from sea buckthorn leaves using the CaO/resin purification-methanol precipitation method. The structure was confirmed using nuclear magnetic resonance (NMR), X-ray diffraction (XRD), ultraperformance liquid chromatography-mass spectrometry (UPLC-MS), and fourier transform infrared spectroscopy (FTIR). QBC was found to extend the lifespan of

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Research summary

L-Quebrachitol extends lifespan by regulating antioxidant activity and autophagy through specific signaling pathways. The study investigates a compound that may influence aging mechanisms directly, aligning with longevity research goals.

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