The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.

Lan Zhou, Hugo Schnack, Edwin van Dellen, Marco P Boks, P Roberto Bakker, Wiepke Cahn, Iris E C Sommer, Marieke J H Begemann

Cognitive Neuroscience Center, University of Groningen, University Medical Center Groningen (UMCG), 9713AP Groningen, The Netherlands. · pubmed

Paper

Abstract

Childhood trauma has been associated with accelerated biological aging, such as early pubertal development and cellular aging. Less is known about the impact of childhood trauma on brain aging, particularly across mental disorders. This cross-sectional study tested the hypothesis that childhood trauma severity is linked to accelerated brain aging using a large discovery MRI dataset. Another independent dataset was included to replicate findings.

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Research summary

Childhood trauma severity is linked to accelerated brain aging. The study addresses the impact of childhood trauma on brain aging, which is relevant to understanding the biological mechanisms of aging and potential interventions.

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