Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia.

Shota Uebo, Yoshiyuki Ikeda, Yoshihiro Uchikado, Yuichi Sasaki, Yuichi Akasaki, Takuro Kubozono, Mitsuru Ohishi

Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan. Electronic address: [email protected]. · pubmed

Paper

Abstract

Aim Sarcopenia, a major cause of frailty in postmenopausal women, is linked to mitochondrial dysfunction, but the underlying mechanisms remain unclear. This study aimed to clarify whether mitophagy, a mitochondrial quality control mechanism, contributes to postmenopausal sarcopenia, to elucidate its underlying mechanism, and to assess whether it can be rescued.

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Research summary

Disruption of Rab9-dependent mitophagy contributes to menopause-induced sarcopenia. This paper is relevant as it investigates the mechanisms of mitochondrial dysfunction in the context of aging and sarcopenia, which are critical factors in the aging process and longevity.

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