Nicotinamide riboside supplementation restores microglial health and improves cognition in aged male mice.

Ramkumar Thiyagarajan, Rupadevi Muthaiah, Bhavana Sreevelu, Owen P Treanor, Yonas Redae, Reem Berman, Anna L Davis, Nanda Yellapu, Spencer R Rosario, Lee D Chaves, Kenneth L Seldeen, Bruce R Troen

Division of Geriatrics, Department of Internal Medicine, Landon Center On Aging, University of Kansas Medical Center, Kansas City, KS, USA. · pubmed

Paper

Abstract

Cognitive impairment affects 1 in 6 individuals over 60, with over 75 million projected by 2030. Age-related changes in microglial function and declining nicotinamide adenine dinucleotide (NAD

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Research summary

Nicotinamide riboside supplementation improves microglial health and cognitive function in aged male mice. The study addresses the underlying mechanisms of aging by focusing on microglial health and NAD levels, which are crucial for maintaining cognitive function in the aging process.

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