Prolonged intermittent hypoxia accelerates cardiovascular aging and mortality: insights from a murine model of OSA.
Abstract
Obstructive sleep apnea (OSA) accelerates cardiovascular aging through intermittent hypoxia (IH). We exposed mice to 22 months of IH, modeling lifelong OSA. Compared to controls, IH mice exhibited higher mortality, elevated blood pressure, impaired systolic and diastolic function, vascular stiffening, reduced coronary reserve, and ECG abnormalities. These findings suggest that chronic IH significantly exacerbates cardiovascular decline with aging, underscoring the importance of early OSA diagnosis and intervention.
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Research summary
Chronic intermittent hypoxia exacerbates cardiovascular decline with aging. The study addresses the impact of obstructive sleep apnea on cardiovascular aging, which is directly related to the mechanisms of aging and age-related diseases.
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