RE-Aging: A functional analysis platform for human RNA editing associated with aging.

Xinyu Pan, Hui Zhang, Weiwen Huang, Wenbin Ma, Zhou Songyang, Yuanyan Xiong

Department of Biochemistry, Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangahou, 510275 Guangdong, China. · pubmed

Paper

Abstract

RNA editing alters mRNA sequences and is linked to aging. We introduce RE-Aging, a platform analyzing age-related RNA editing using GTEx data (259,620 A-to-I and 30,502 C-to-U sites across 27 tissues). Features include site exploration, age correlations, gene annotation, RNA structure analysis, and miRNA binding impact. Supports differential editing analysis (Wilcoxon test) and single-cell RNA editing age mapping for blood cells. Access at http://bioinfo-sysu.com/RE-Aging/.

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Research summary

The paper claims to provide a functional analysis platform for studying age-related RNA editing. The research addresses mechanisms associated with aging, which is directly relevant to understanding the biological processes of aging and potential interventions.

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