Unequal expression: Social position modulates APOE genotype risk of dementia.

José M Aravena, Xi Chen, Becca R Levy

Department of Social & Behavioral Sciences, School of Public Health, Yale University, New Haven, Connecticut, United States of America.Department of Social & Behavioral Sciences, School of Public Health, Yale University, New Haven, Connecticut, United States of America. · pubmed

Paper

Abstract

Although social position plays a pivotal role in cognitive aging, most dementia prevention strategies and risk prediction models continue to emphasize biomedical and genetic factors (particularly APOE status). This disconnect raises critical questions about how social environments may shape the effect of genetic risk on dementia. We examined how APOE alleles interact with social adversity to determine dementia risk.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that social adversity interacts with APOE genotype to influence dementia risk. This research is relevant as it explores the interplay between genetic factors and social determinants in cognitive aging, addressing a broader understanding of dementia risk beyond purely biomedical approaches.

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