Dietary glycyrrhizin enhances reproductive performance by improving intestinal microbiota, liver lipid metabolism and ovarian senescence in aged breeder hens.

Zhenwu Huang, Huchuan Liu, Guangju Wang, Huan Ge, Yanru Shi, Jinghai Feng, Chunmei Li, Minhong Zhang

State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China. · pubmed

Paper

Abstract

The decline in reproductive performance of aged hens is mainly attributed to oxidative damage in reproductive organs, hepatic lipid metabolism disorders, and intestinal microbiota dysbiosis. Glycyrrhizin (GL) has been proven to enhance antioxidant capacity, regulate lipid metabolism and gut microbiota in mammals, but its efficacy in hens remains unclear. Hence, this study aimed to investigate whether dietary GL supplementation improves reproductive performance in hens during the late laying stage by modulating intestinal microbiota composition, hepatic lipid metabolism and ovarian antioxidant status.

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Research summary

Dietary glycyrrhizin supplementation improves reproductive performance in aged hens by modulating intestinal microbiota, hepatic lipid metabolism, and ovarian antioxidant status. The study addresses factors related to aging in reproductive performance, suggesting potential mechanisms that could influence longevity in a specific context.

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