High glucose-induced mitophagy accelerates premature aging of T cells in patients with rheumatoid arthritis.

Jiaxin Lei, Yongao Wen, Lingyi Li, Huiyan Ji

Institutes of Biology and Medical Sciences, The Fourth Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Soochow University, Suzhou, Jiangsu, 215123, China. [email protected]. · pubmed

Paper

Abstract

Premature T cell aging, marked by telomere shortening and cell cycle arrest, plays a key role in the pathogenesis of rheumatoid arthritis (RA). Growing evidence suggests that high glucose-induced metabolic dysfunction critically regulates both cellular aging and RA progression. This study explores how high glucose exacerbates T cell aging, providing novel insights into the mechanisms underlying RA development.

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Research summary

High glucose exacerbates T cell aging in rheumatoid arthritis patients. The paper addresses mechanisms of cellular aging, which is directly relevant to understanding and potentially mitigating age-related dysfunctions.

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