Unveiling proteomic and peptide-level modifications in cerebrospinal fluid and plasma in normal cognitive aging.

Aida Kamalian, Polina Shichkova, Marco Tognetti, Christopher Below, Sara G Ho, Roland Bruderer, Lukas Reiter, Yuehan Feng, Michael W Lutz, Abhay Moghekar

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. · pubmed

Paper

Abstract

Normal cognitive aging is accompanied by molecular changes in the brain and periphery, but the specific proteomic and peptide-level alterations remain poorly defined. This study aimed to characterize age-related protein and peptide modifications by analyzing matched cerebrospinal fluid (CSF) and plasma samples from cognitively normal individuals.

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Research summary

This study characterizes age-related protein and peptide modifications in cerebrospinal fluid and plasma. The research addresses molecular changes associated with normal cognitive aging, which is relevant to understanding the biological processes of aging.

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