The Ets2 super-enhancer modulates endothelial-mesenchymal transition during cardiac aging.

Zhenglong Guo, Lan Li, Junwei Luo, Wei Xue, Shasha Bian, Yongchang Zhu, Dawei Huo, Wenke Yang, Jing Ma, Yibin Hao, Guanwei Fan, Bingtao Hao, Shixiu Liao

Henan Provincial Key Laboratory of Genetic Diseases and Functional Genomics, Medical Genetics Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450000, China. · pubmed

Paper

Abstract

Cardiac aging is characterized by endothelial dysfunction and associated cardiovascular pathologies, often involving endothelial-to-mesenchymal transition (EndoMT) in cardiac endothelial cells. While the transcription factor Ets2, a member of the Ets family, is known to regulate endothelial cell survival and function, its role in EndoMT and cardiac aging remains poorly understood.

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Research summary

The paper claims that the Ets2 super-enhancer plays a role in modulating endothelial-mesenchymal transition during cardiac aging. This research is relevant as it explores mechanisms underlying endothelial dysfunction in aging, which could contribute to understanding and potentially addressing root causes of age-related cardiovascular diseases.

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