A multi-omics molecular landscape of 30 tissues in aging female rhesus macaques.

Gong-Hua Li, Xiang-Qing Zhu, Fu-Hui Xiao, Xilong Zhao, Longbao Lv, Fan-Qian Yin, Le Chang, Ming-Xia Ge, Qiang Wang, Jing Zhao, Chuan Tian, Zian Li, Guangping Ruan, Rongqing Pang, Jing Gao, Lihua Ma, Xing-Hua Pan, Qing-Peng Kong

State Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China.State Key Laboratory of Genetic Evolution & Animal Models, National Resource Center for Non-Human Primates, Kunming Primate Research Center, Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Key Laboratory of Healthy Aging Research of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China. · pubmed

Paper

Abstract

A systematic investigation of aging patterns across virtually all major tissues in nonhuman primates, our evolutionarily closest relatives, can provide valuable insights into tissue aging in humans, which is still elusive largely due to the difficulty in sampling. Here, we generated and analyzed multi-omics data, including transcriptome, proteome and metabolome, from 30 tissues of 17 female rhesus macaques (Macaca mulatta) aged 3-27 years. We found that certain molecular features, such as increased inflammation, are consistent across tissues and align with findings in mice and humans. We further revealed that tissue aging in macaques is asynchronous and can be classified into two distinct types, with one type exhibiting more pronounced aging degree, likely associated with decreased mRNA translation efficiency, and predominantly contributing to whole-body aging. This work provides a comprehensive molecular landscape of aging in nonhuman primate tissues and links translation efficiency to tissue-specific aging.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that tissue aging in macaques is asynchronous and can be classified into distinct types linked to translation efficiency. This research is relevant as it investigates the molecular mechanisms of aging in nonhuman primates, which can provide insights into the root causes of aging and potential interventions for lifespan extension.

Author of this paper? Send a correction.