Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries.

Gry Freja Skovsted, Alex Aupetit, Karl Björling, Kristian Agmund Haanes, Susanne Syberg, Niklas Rye Jørgensen, Blanca I Aldana, Hirotsugu Tsuchimochi, Mark T Waddingham, Kristine Freude, James Todd Pearson, Lars Jørn Jensen

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Science, University of Copenhagen, Frederiksberg, Denmark. · pubmed

Paper

Abstract

Ageing is a risk factor for cardiovascular and neurodegenerative diseases. The myogenic response in resistance arteries is responsible for basal (myogenic) tone and blood flow autoregulation. G-protein-coupled receptors and G

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Research summary

The paper investigates the role of S1P- and Rho-kinase signaling in age-related myogenic tone deficiency in murine resistance arteries. This research is relevant as it addresses mechanisms underlying vascular aging, which is a critical aspect of longevity and age-related diseases.

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