Reduced Circulating α-Klotho Levels Are Associated With Elevated Mortality and Arterial Calcifications of Aorta and Iliac Arteries.

Elias Hellou, Parvin Kalhor, Ali Babaie, Nadia Akhiyat, Negin Mahmoudi Hamidabad, Valentina Nardi, Matteo Manzato, Kai Nogami, Elizabeth Copley, Lilach O Lerman, Amir Lerman

Department of Cardiovascular Medicine Mayo Clinic Rochester MN USA.Department of Cardiovascular Medicine Mayo Clinic Rochester MN USA. · pubmed

Paper

Abstract

α-Klotho is a multifunctional protein implicated in vascular aging. Declining Klotho levels are associated with arterial stiffness, endothelial dysfunction, and vascular calcification. We investigated the associations between circulating klotho, aortoiliac calcification, endothelial progenitor cells, and 10-year survival.

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Research summary

Reduced circulating α-Klotho levels are associated with elevated mortality and arterial calcifications. The study investigates a biomarker linked to vascular aging, which is directly relevant to understanding the mechanisms of aging and potential interventions for longevity.

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