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Leonie Jt Balter, Jonatan Malmros, Per Stenkrona, Andrea Varrone, Anton Forsberg, Erik Gustavsson, Cedrique E Mouyobo, Grégoria Kalpouzos, Goran Papenberg

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, 171 65, Sweden. [email protected]. · pubmed

Paper

Abstract

Sleep disturbances and inflammation are interconnected through shared regulatory mechanisms and are both implicated in age-related diseases. However, their connection at the level of brain-specific inflammation remains underexamined in humans. This study investigated whether specific dimensions of sleep are associated with microglial density, as measured by translocator protein (TSPO) levels, a biomarker of neuroinflammation. TSPO levels were measured using a single [

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that specific dimensions of sleep are associated with microglial density, indicating a link between sleep disturbances and neuroinflammation. This research is relevant as it explores the underlying mechanisms connecting sleep and inflammation, which are both critical factors in age-related diseases and longevity.

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