Targeted clearance of senescent cells alleviates alcohol-associated liver disease by restoring cellular function and immune balance.

Tian Tian, Yuhua Xue, Zhewei Song, Brady Jin-Smith, Joshua Barkin, Melak Ottallah, Mahfuza Mannan, Arina Zhirkova, Daohong Zhou, Liya Pi

Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA.Department of Pathology, Tulane University School of Medicine, New Orleans, LA, 70112, USA. · pubmed

Paper

Abstract

The liver is one of the organs most affected by alcohol consumption, and its interaction with aging is particularly significant. Chronic alcohol consumption accelerates liver aging through mechanisms such as oxidative stress, inflammation, fibrosis, and impaired regeneration. It is still unknown whether senescent cell clearance orchestrates innate and adaptive immune responses during the alcohol-induced old liver damage process. To investigate this, we used INK-ATTAC transgenic mice treat with AP20187 (AP) to eliminate p16

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Research summary

Targeted clearance of senescent cells can restore cellular function and immune balance in alcohol-associated liver disease. The paper addresses the role of senescent cell clearance in mitigating age-related liver damage, which is directly related to the underlying mechanisms of aging and longevity.

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