The drug discovery and therapeutic nano-strategies targeting cellular senescence.

Yumei Wang, Mingqi Liu, Xinzhao Chen, Song Wang, Jiatong Li, Yuman Sun, Xuting Zheng, Jianxiang Zhang, Heran Li

Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China.Department of Pharmaceutics, College of Pharmacy, Army Medical University, Chongqing, 400038, China. · pubmed

Paper

Abstract

Cellular senescence is a primary driver of aging, where damaged or senescent cells (SnCs) continuously accumulate in the body, altering the local tissue environment and causing various pathologies in different organs or tissues, offering brand-new diagnostic and therapeutic possibilities for aging-related disease. This review begins by discussing the multiple molecular mechanisms of cellular senescence. We mainly focus on the therapeutic strategies and their clinical applications targeting cellular senescence, where senolytic and senomorphic drugs are currently two main categories of anti-aging therapies. Besides, nicotinamide adenine dinucleotide (NAD

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Research summary

The paper discusses therapeutic strategies targeting cellular senescence as a root cause of aging. This research is relevant as it addresses the underlying mechanisms of aging and explores potential interventions to mitigate age-related diseases.

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