HMGB2 Deficiency in Bone Marrow Mesenchymal Stem Cells Promotes Age-Related Osteoporosis by Inhibiting Osteoblast Differentiation via Inflammatory Factors.

Zhiliang Li, Yuqing Cai, Yao Lu, Baoshuo Qian, Wenxiu Yan, Hongwei Gao, Jing Zhao

Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, School of Life Sciences, Shandong University, Qingdao, China. · pubmed

Paper

Abstract

With the global rise in osteoporosis due to aging, impaired osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) has emerged as a critical pathogenic factor. Although high mobility group box 2 (HMGB2) is implicated in BMSC aging and organismal senescence, its mechanistic role in osteoporosis remains unclear. Here, we investigate HMGB2's regulatory effects on BMSC osteogenic differentiation under aging conditions. Using an H

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Research summary

HMGB2 deficiency in BMSCs inhibits osteoblast differentiation, promoting age-related osteoporosis. The study addresses a mechanistic understanding of aging-related bone loss, which is crucial for developing interventions targeting the root causes of age-related diseases.

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