iPSCs derived sEVs ameliorate NK cell senescence by targeting CISH-STAT3.

Yu Chen, Rongrong Cao, Zhengsheng Chen, Juntao Zhang, Yajing Ren, Xin Niu, Ji Yuan, Lei Luo, Shuxiang Yu, Yang Wang, Qing Li

Institute of Microsurgery on Extremities, Department of Orthopedic Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China. · pubmed

Paper

Abstract

Natural killer (NK) cells, essential components of the innate immune system, undergo subtype changes with aging that diminish their cytotoxic and tumor surveillance functions. Recent reports indicate that small extracellular vesicles (sEVs) derived from stem cells could ameliorate age-related diseases, while their effects on NK cell senescence remain unexplored.

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Research summary

The paper claims that iPSCs derived small extracellular vesicles can reduce NK cell senescence by targeting the CISH-STAT3 pathway. This research is relevant as it explores a potential mechanism to mitigate cellular senescence, which is a key factor in aging and age-related decline in immune function.

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