Proteome organ aging and cardiometabolic risk in a population at risk for heart failure.

Kaiyong Qu, Elisa Dal Canto, Anne-Mar L N van Ommen, Sabrina Abou Kamar, Arco J Teske, Maarten Jan Cramer, Marianne C Verhaar, Dirk J Duncker, Frans H Rutten, Isabella Kardys, Roxana Menken, Leonard Hofstra, Igor I Tulevski, G Aernout Somsen, N Charlotte Onland-Moret, Ernest Diez Benavente, Hester M den Ruijter

Laboratory of Experimental Cardiology, University Medical Center Utrecht, Room Number G02-404, Utrecht University, Utrecht, The Netherlands. [email protected]. · pubmed

Paper

Abstract

Biological aging varies across individuals and tissues, influencing chronic diseases, including heart failure (HF). Emerging proteome techniques enable quantification of organ-specific aging acceleration (OAA), but whether OAA relates to HF severity and differs by sex remains unclear. We aim to assess the sex-related association between OAA of heart, artery and kidneys and HF severity, and to investigate relevant cardiometabolic risk factors of organ aging.

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Research summary

The paper investigates the relationship between organ aging and heart failure severity, with a focus on sex differences and cardiometabolic risk factors. This research is relevant as it explores the biological mechanisms of aging and their impact on chronic diseases, which aligns with the broader goals of longevity research.

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