Proinflammatory Macrophage-Targeted Nanoparticles Rejuvenate Aged Macrophages and Their Phagocytic Capacity.

Donglin Cai, Zhelun Li, Wendong Gao, Jiaying Liu, Xiaying Qi, Jie Jin, Yufeng Zhang, Qing Zhang, Lan Xiao, Yin Xiao

School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, Australia.School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Gold Coast, QLD 4222, Australia. · pubmed

Paper

Abstract

Aging profoundly compromises immune homeostasis, leaving elderly individuals highly vulnerable to inflammatory diseases. Central to this process is macrophage dysfunction, as macrophages progressively shift toward a pro-inflammatory M1 phenotype with excessive inflammation and impaired phagocytosis. This diminished phagocytic capacity not only weakens host defense but also limits the therapeutic efficacy of nanoparticle (NP)-based antisenescence interventions due to the reduced cellular uptake. Therefore, reversing cellular inflammation and restoring the function of senescent macrophages are crucial in treating inflammatory diseases in the elderly. This article presents an M1-targeted NP to rejuvenate aged macrophages and restore their phagocytosis. Gold nanocages (AuNCs) were camouflaged with

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Research summary

The paper claims that M1-targeted nanoparticles can rejuvenate aged macrophages and restore their phagocytic capacity. This research addresses the dysfunction of macrophages in aging, which is a root cause of immune system decline and inflammatory diseases in the elderly, making it relevant to longevity research.

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