Expanded mosaic chromosomal alterations, frailty, and risks of all-cause and cause-specific mortality among Chinese and the UK adults: evidence from two prospective cohorts.

Mingyu Song, Zilun Shao, Yuting Han, Yuxuan Zhao, Jun Lv, Canqing Yu, Pei Pei, Ling Yang, Iona Y Millwood, Robin G Walters, Yiping Chen, Huaidong Du, Xiaoming Yang, Mengwei Wang, Junshi Chen, Zhengming Chen, Giulio Genovese, Chikashi Terao, Liming Li, Dianjianyi Sun

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China. · pubmed

Paper

Abstract

Mosaic chromosomal alterations (mCAs) served as a novel indicator of genomic aging. We aimed to investigate the association of expanded mCAs (cell fraction ≥ 10%) with all-cause and cause-specific mortality, and to examine the joint effect of expanded mCAs and frailty index (FI), an indicator of phenotypic aging, on mortality in two large prospective cohorts.

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Research summary

The paper claims that expanded mosaic chromosomal alterations are associated with increased mortality risk and interact with frailty index in predicting mortality. This research is relevant as it explores genomic aging indicators and their relationship with mortality, contributing to the understanding of aging mechanisms.

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