Sirt6 prevents the age-related decline of H

Noga Touitou, Liat Nahum, Sarit Feldman-Trabelsi, Matan Y Avivi, Miguel A Aon, Shoshana Naiman, Moran Rathaus, Asaf A Gertler, Asael Roichman, Lia Berkman Dvir, Michel Bernier, Nirad Banskota, Lir Beck, Ron Nagar, Zacharia Schwartz, Nathan L Price, Michal Harel, Batia Lerrer, Isao Ishii, Hanoch Senderowitz, Ruin Moaddel, Tamar Geiger, Rafael de Cabo, Haim Y Cohen

The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. · pubmed

Paper

Abstract

Mice overexpressing Sirt6 or fed a caloric restriction (CR) diet live longer with improved health. CR increases Sirt6 levels, and its beneficial effects are mediated by the gasotransmitter H

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Sirt6 overexpression or caloric restriction enhances lifespan and health in mice through the gasotransmitter H. This research addresses mechanisms that could potentially mitigate age-related decline, aligning with the goal of understanding and combating the root causes of aging.

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