Endothelial LRRC8A delays vascular ageing in natural and accelerated ageing mouse models.

Jinlong Pang, Lei Pan, Wei Shen, Gangsi Yi, Xu Kong, Heqiang Zhang, Baolong Feng, Hu Sun, Liangcai Chen, Guiyang Li, Hui Zhuang, Jiajin Chen, Lin Lu, Yan Wang, Lingjun Jie, Yanhui Zhang

Institute of Cardiovascular Diseases, Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China. · pubmed

Paper

Abstract

Vascular ageing (VA), characterized by vascular endothelial dysfunction, is a major contributor to age-related chronic conditions. Leucine-rich repeat-containing protein 8A (LRRC8A) is vital in maintaining vascular endothelial function; however, the role of endothelial LRRC8A in VA is undefined. We aimed to investigate the role and mechanism of endothelial LRRC8A in VA.

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Research summary

Endothelial LRRC8A plays a crucial role in delaying vascular ageing. The study addresses a fundamental aspect of vascular ageing, which is a key contributor to age-related chronic conditions, thus contributing to the understanding of mechanisms that could potentially mitigate the effects of aging.

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