Galangin alleviates vascular aging and endothelial cell senescence by targeting SMAD3 to initiate mitophagy.

Xiao-Qing Ding, Ke-Xin Li, Jing-Wen Liu, Rui-En Zhang, Chun-Ran Lei, Zi-Xin Yi, Ke Li, Peng-Xia Liu, Rui Yang, Chang-Shan Wang

School of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010020, China.School of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia 010020, China. · pubmed

Paper

Abstract

Senescence of vascular endothelial cells (ECs) plays a critical role in cardiovascular diseases. Galangin (3,5,7-Trihydroxyflavone) is a flavonoid derived from plants and medicinal herbs with various biological activities. However, its effect on endothelial cell senescence and the underlying molecular mechanisms are poorly characterised.

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Research summary

Galangin targets SMAD3 to initiate mitophagy, alleviating vascular aging and endothelial cell senescence. The paper addresses the mechanisms of endothelial cell senescence, which is a fundamental aspect of vascular aging and has implications for longevity and age-related diseases.

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