Germline regulation of the intestinal mitochondrial unfolded protein response.
Abstract
The disposable soma theory posits that there is a trade-off between reproduction and somatic maintenance. In support of this theory, we previously identified that pharmacological inhibition of the germline has widespread protective cell non-autonomous effects on cellular protein homeostasis in the model organism Caenorhabditis elegans. However, the cell non-autonomous effects of the germline on mitochondrial protein homeostasis are not well defined. Here, we use pharmacological or genetic inhibition of the germline to determine its effects on intestinal mitochondrial protein homeostasis as measured by the mitochondrial unfolded protein response (UPR
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Research summary
The paper claims that germline inhibition affects intestinal mitochondrial protein homeostasis through the mitochondrial unfolded protein response. This research explores the relationship between germline regulation and mitochondrial function, which are both critical factors in the aging process and longevity.
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