Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation.

Taotao Mi, Shanshan Yang, Nan Wang, Fengjiao Huo, Meili Zhao, Shuyao Lv, Tingting Su, Shengyu Feng, Hao Wang, Liuling Guo, Jian-Kang Zhu, Hailiang Liu

Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, China.Institute for Regenerative Medicine, State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200123, China. · pubmed

Paper

Abstract

Immune function decline (immunosenescence) accelerates systemic aging and adversely impacts cognitive function. Antioxidants may mitigate these effects; however, the role of ascorbic acid (AA), a key antioxidant, in counteracting immunosenescence and enhancing cognition remains inadequately explored.

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Research summary

Ascorbic acid may mitigate immunosenescence and cognitive decline through MYH9-mediated CD8⁺ T cell differentiation. The paper addresses the role of antioxidants in combating immunosenescence, which is a key factor in aging and age-related cognitive decline, thus contributing to the understanding of potential interventions in the aging process.

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