Intranasal Insulin Mitigates Memory Impairment and Neuroinflammation in a Mouse Model of Hippocampal Aging.

Rajasekar Nagarajan, Han Zhang, Jinrui Lyu, Maltesh Kambali, Muxiao Wang, Uwe Rudolph

Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.Department of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. · pubmed

Paper

Abstract

Aging is a complex process that frequently includes cognitive decline with memory loss. In the hippocampus, the number of somatostatin-positive (Sst

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Intranasal insulin administration can reduce memory impairment and neuroinflammation in aging mice. This study addresses cognitive decline associated with aging, suggesting a potential intervention that targets mechanisms underlying age-related memory loss.

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