Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice.

Lars Saemann, Lotta Hartrumpf, Adrian-Iustin Georgevici, Sabine Pohl, Anne Großkopf, Kristin Wächter, Yuxing Guo, Andreas Simm, Gábor Szabó

Department of Cardiac Surgery, University Hospital Halle, Martin-Luther University Halle-Wittenberg, 06120, Halle (Saale), Germany. · pubmed

Paper

Abstract

Vascular aging is associated with endothelial dysfunction, changes in vascular elasticity or stiffness, and the prevalence of cardiovascular diseases. Aging differs by sex. The effects of age, sex, and vessel region on arterial vasomotor function and gene expression signatures have not been explored yet. Thus, we investigated contraction, relaxation, and endothelial integrity, as well as gene expression, in the proximal and distal segments of the thoracic aorta in 6- and 18-month-old mice.

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Research summary

The paper investigates how age, sex, and vessel region influence vasomotor function and gene expression in the aorta of mice. This research is relevant as it explores the biological mechanisms underlying vascular aging, which is a key aspect of longevity and age-related diseases.

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