Endocrine, Metabolic, and Skeletal Muscle Proteomic Responses During Energy Deficit With Concomitant Aerobic Exercise in Humans.

Yusuke Nishimura, Carl Langan-Evans, Harry L Taylor, Wee L Foo, James P Morton, Sam Shepherd, Juliette A Strauss, Jatin G Burniston, José L Areta

Faculty of Health, Innovation, Technology and Science, Tom Reilly Building, Liverpool John Moores University, Liverpool, UK. · pubmed

Paper

Abstract

Energy deficit is a potent physiological stressor that has shaped human evolution and can improve lifespan and healthspan in a wide range of species. Preserving locomotive capacity was likely essential for survival during the human hunter-gatherer period but surprisingly little is known about the molecular effects of energy deficit on human skeletal muscle, which is a key tissue for locomotion and metabolic health. Here we show that after a 5-day 78% reduction in energy availability with concomitant aerobic exercise in healthy men there was a profound modulation of skeletal muscle phenotype alongside increases in fat oxidation at rest and during exercise and a 2.1 ± 0.8 kg loss of fat free mass and 0.8 ± 0.6 kg of fat mass. We used stable isotope (D

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Research summary

The paper claims that a 5-day energy deficit with aerobic exercise leads to significant changes in skeletal muscle phenotype and fat oxidation. This research is relevant as it explores the physiological responses to energy deficit, which may have implications for metabolic health and longevity.

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