Cardiorespiratory fitness and type 2 diabetes risk: A prospective cohort study with mediation analysis of biological aging in the UK Biobank.

Xiangliang Liu, Xinqiao Chen, Wang Yang, Guanran Ding, Yixin Zhao, Yuguang Li, Naifei Chen, Jiuwei Cui

Cancer Center, The First Hospital of Jilin University, Changchun, China.Cancer Center, The First Hospital of Jilin University, Changchun, China. · pubmed

Paper

Abstract

Higher cardiorespiratory fitness is associated with reduced type 2 diabetes mellitus (T2D) risk, but the underlying mechanisms remain incompletely understood. We investigated whether biological aging mediates the association between maximal oxygen uptake (VO

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Higher cardiorespiratory fitness is associated with reduced type 2 diabetes risk through the mediation of biological aging. This study explores a potential mechanism linking fitness and aging, which is relevant to understanding and addressing the root causes of age-related diseases.

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