Jianpi Qiangji Granule ameliorates aging-associated sarcopenia via AMPK/PGC-1α axis in SAMP8 mice.

Zhe Pan, Yujie Zhang, Jiali Zhang, Linzhang Zhang, Qinying Feng, Jingjing Zhang, Yushi Yao, Wei Liu, Weian Yuan

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. · pubmed

Paper

Abstract

Sarcopenia is an age-related syndrome characterized primarily by the progressive decline of muscle mass and function. It is frequently associated with adverse outcomes such as falls, fractures, and hospitalization, often leading to substantial economic burdens and severe health hazards. At present, effective pharmacological treatments for sarcopenia remain unavailable. Jianpi Qiangji Granule (JQG), a traditional Chinese medicine formula, have demonstrated significant therapeutic effects in both clinical and preclinical studies. However, its mechanism of action remains unclear.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

Jianpi Qiangji Granule improves muscle mass and function in aging-associated sarcopenia through the AMPK/PGC-1α pathway. The paper addresses a significant age-related condition, sarcopenia, and explores a potential therapeutic intervention, contributing to the understanding of aging-related health issues.

Author of this paper? Send a correction.