Age-related decline in protein turnover highlights cystatin C dysfunction and links proteostasis collapse to neuroinflammation in the murine cortex.

Daiana Burdusel, Sina Ghaemmaghami, Diana-Larisa Ancuta, Coman Cristin, Dirk Hermann, Thorsten Doeppner, Denisa F V Pirscoveanu, Aurel Popa-Wagner

Doctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania.Doctoral School, University of Medicine and Pharmacy Craiova, 200349, Craiova, Romania. · pubmed

Paper

Abstract

One of the key hallmarks of aging is the breakdown of proteostasis-the finely tuned balance of protein synthesis, folding, trafficking, and degradation that maintains proteome integrity and cellular function. In this study, we employed

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Research summary

The paper claims that age-related decline in protein turnover is linked to cystatin C dysfunction and neuroinflammation in the murine cortex. This research addresses the underlying mechanisms of proteostasis collapse, which is a critical aspect of aging and longevity.

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