Parental clinical manifestation association with newborn immune senescence and telomere biology in Pakistan.

Sadia Farrukh, Saeeda Baig

Department of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan. [email protected] of Biological and Biomedical Sciences, Aga Khan University, Stadium Road, P.O. Box 3500, Karachi, 74800, Pakistan. [email protected]. · pubmed

Paper

Abstract

This study investigates the association of parental clinical manifestations with newborn telomere biology and immune senescence markers, utilising 204 parent-newborn triads in Karachi, Pakistan. The demographic data collection was followed by quantification of telomere length (TL) using quantitative PCR, while Sanger sequencing was performed to analyse variants in telomerase genes [Telomere Reverse Component (TERC) and Telomerase Reverse Transcriptase (TERT)]. Moreover, flow cytometry was used to analyse immune senescence markers CD57 and Killer cell lectin-like receptor G1 (KLRG1).

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Research summary

The paper claims that parental clinical manifestations are associated with newborn telomere biology and immune senescence markers. This research is relevant as it explores the biological mechanisms underlying aging and immune function, which are critical to understanding longevity.

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