Dietary iron attenuates epigenetic aging through DNA methylation remodeling and extends survival in older adults.
Abstract
Iron homeostasis is essential for fundamental biological processes, yet its impact on epigenetic aging and mortality remains poorly understood. This study aimed to investigate associations between dietary iron intake and DNA methylation (DNAm) aging markers and to determine whether these epigenetic signatures mediate iron's effects on mortality outcomes.
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Research summary
Dietary iron intake is associated with DNA methylation changes that may influence mortality outcomes in older adults. This paper is relevant as it explores the relationship between dietary factors and epigenetic aging, potentially addressing mechanisms that contribute to longevity and age-related health outcomes.
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