Mesenchymal stem cell derived extracellular vesicles reverses neural aging via OSKM modulation.

Chul Kim, Soo-Hyeon Nam, Jae Hyun Park, Chul-Woo Lim, Jin Young Lee, Yun-Hwa Jeong, Youngsook Song, Moonbeom Choi, Seungmin Lee, Ji Hyung Chung, Jisook Moon

RE-CODE, 43, Beolmal-ro 30beon-gil, Bundang-gu, Seongnam-si, 13503, Gyeonggi- do, Republic of Korea.RE-CODE, 43, Beolmal-ro 30beon-gil, Bundang-gu, Seongnam-si, 13503, Gyeonggi- do, Republic of Korea. · pubmed

Paper

Abstract

Intravenously infused human placenta-derived mesenchymal stem cells enhance overall function and exhibit therapeutic potential even with minimal engraftment or tissue replacement, with substances released from human placenta-derived mesenchymal stem cells playing a significant role in these positive outcomes. Stem cell-derived extracellular vesicles transfer beneficial factors that aid recovery in various tissues through genetic regulation. However, the effects of systemically injected mesenchymal stem cells and their released derivatives on normal aging have not been reported.

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Research summary

The paper claims that mesenchymal stem cell-derived extracellular vesicles can reverse neural aging through OSKM modulation. This research is relevant as it explores potential mechanisms to address the underlying processes of aging rather than merely treating age-related symptoms.

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