Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.

Dominik Saul, Diana Jurk, Madison L Doolittle, Robyn Laura Kosinsky, Yeaeun Han, Xu Zhang, Ana Catarina Franco, Sung Y Kim, Saranya P Wyles, Y S Prakash, David G Monroe, Luigi Ferrucci, Nathan K LeBrasseur, Paul D Robbins, Laura J Niedernhofer, Sundeep Khosla, João F Passos

Division of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. [email protected]. · pubmed

Paper

Abstract

Senescent cells drive age-related tissue dysfunction via the induction of a chronic senescence-associated secretory phenotype (SASP). The cyclin-dependent kinase inhibitors p21

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims to identify distinct senotypes in p16- and p21-positive cells across aging tissues. This research is relevant as it explores the mechanisms of cellular senescence, which are fundamental to understanding the root causes of aging and potential interventions for age-related dysfunction.

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