Longevity-promoting mitochondrial unfolded protein response activation requires elements of the PeBoW complex.

Adebanjo Adedoja, Niclole Stuhr, Yifei Zhou, Yuyao Zhang, Armen Yerevanian, Alexander A Soukas

Department of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.Department of Medicine, Diabetes Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. · pubmed

Paper

Abstract

Mitochondria play a crucial role in cellular energy metabolism and homeostasis and are strongly implicated in aging and age-related diseases. The outer mitochondrial membrane protein voltage-dependent anion channel (VDAC) plays multiple roles in mitochondrial homeostasis, including transport of metabolites, ATP, and Ca

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Research summary

The paper claims that activation of the mitochondrial unfolded protein response, which is linked to longevity, requires elements of the PeBoW complex. This research is relevant as it explores mechanisms that could influence mitochondrial function and aging, potentially addressing root causes of age-related decline.

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