Ejiao alleviates sarcopenia by AKT/mTOR/Foxo3a and AMPK pathways in an aging rat model induced by D-Galactose combined with restricted movement.

Hongwei Zhang, Shan Liu, Qin Feng, Haibin Liu, Juan Wu, Xiaobo Duan, Zhengjuan Li, Yue Zhang, Xiaoying Zhou, Mingchao Yv, Chuyi Liu, Jie Cheng, Guanhua Du, Lili Zhao

Marine Biomedical Research Institute of Qingdao, Ocean University of China, Qingdao, 266003, China; School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China. · pubmed

Paper

Abstract

Ejiao (Asini Corii Colla, donkey-hide gelatin from the hide of Equus asinus Linnaeus., ACC) is a traditional Chinese medicine (TCM) which has a long history and wide application in "nourishing Qi and nourishing blood".

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Research summary

Ejiao alleviates sarcopenia through the modulation of AKT/mTOR/Foxo3a and AMPK pathways in aging rats. The study addresses sarcopenia, a condition associated with aging, and explores mechanisms that could potentially mitigate age-related muscle loss, thus contributing to longevity research.

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