Exhausted CD8

Yee Teng Chan, Kar Min Loh, Zhi Ying Phong, Ting Fang Tang, Chun Howe Ng, Alireza Saeidi, Heng Choon Cheong, Yi Ying Cheok, Rong Xiang Ng, Raja Iskandar Shah Raja Azwa, Kian-Kai Cheng, Chung Yeng Looi, Adeeba Kamarulzaman, Reena Rajasuriar, Won Fen Wong

Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. · pubmed

Paper

Abstract

In people living with HIV (PLWH), persistent viral replication and antiretroviral therapy (ART)-associated toxicity contribute to T cell exhaustion, characterised by significant metabolic reprogramming that negatively impacts cellular function and longevity. Understanding the metabolic dysregulation in exhausted T cells could unveil novel therapeutic strategies to rejuvenate immune responses in PLWH. This study investigated the prevalence and metabolic gene expression profiles of exhausted CD8

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Research summary

The paper investigates the metabolic dysregulation in exhausted CD8 T cells in people living with HIV. This research is relevant as it addresses the mechanisms of T cell exhaustion, which can be linked to immune aging and longevity, potentially leading to therapeutic strategies that rejuvenate immune responses.

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