PRDX5 Regulates Mitochondrial Function and Nuclear Spreading in Myogenesis and Acts With PRDX3 to Delay Muscle Aging.

Joonho Suh, Je-Hyun Eom, Jongmin Baik, Wonn Shim, Max A Tischfield, Hyun Ae Woo, Yun-Sil Lee

Department of Molecular Genetics, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, Republic of Korea. · pubmed

Paper

Abstract

Skeletal muscle aging is associated with oxidative stress and mitochondrial dysfunction. Peroxiredoxins (PRDXs), particularly PRDX3 and PRDX5, are antioxidant enzymes that are uniquely localized to mitochondria. While PRDX3 has been reported to play a role in maintaining mitochondrial function in muscle, the specific function of PRDX5 in muscle remains unclear. This study investigated the role of PRDX5 in mitochondrial function, myonuclear distribution and muscle aging.

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Research summary

PRDX5 plays a role in mitochondrial function and myonuclear distribution, which are critical for muscle aging. The study addresses mechanisms related to oxidative stress and mitochondrial dysfunction, which are fundamental aspects of the aging process.

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