Long-term BMI trajectories and epigenetic age acceleration: the role of genetic risk for obesity.

Yue Wen, Yi Chen, Yanling Ma, Chunyan Lu, Yizhuo Liu, Ruiyuan Zhang, Jing Liao, Dongmei Wu, Changwei Li

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, 37 Guoxue Xiang Street, Chengdu, Sichuan Province, 610041, China.Department of Gastrointestinal Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, 37 Guoxue Xiang Street, Chengdu, Sichuan Province, 610041, China. · pubmed

Paper

Abstract

Previous studies reported mixed findings in the relationship between body mass index (BMI) and epigenetic age acceleration (EAA), while none considered long-term trajectory of BMI and individuals' genetic background. Therefore, we aimed to evaluate the joint effects of long-term BMI trajectory and genetic risk for obesity on EAA among older US adults.

The following analysis is generated by AI and may contain errors. It is separate from the authors’ abstract and is not peer review.

Research summary

The paper claims that long-term BMI trajectories and genetic risk for obesity jointly influence epigenetic age acceleration in older adults. This research is relevant as it explores the interplay between obesity, genetics, and biological aging, potentially addressing root causes of aging and longevity.

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