Metabolic regulation of behavior by the intestinal enzyme FMO-2.

Elizabeth S Kitto, Safa Beydoun, Ella Henry, Megan L Schaller, Mira Bhandari, Sarah A Easow, Angela M Tuckowski, Marshall B Howington, Ajay Bhat, Aditya Sridhar, Eugene Chung, Charles R Evans, Scott F Leiser

Molecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA.Molecular and Integrative Physiology Department, University of Michigan, Ann Arbor, MI, USA. · pubmed

Paper

Abstract

Many elements of an organism's behavior are intertwined with the organism's health. Over a long period of time, health status is also indicative of life span, with improved health correlating with a longer life. However, the relationship between longevity and behavior remains relatively unexplored. Here, we report that modification of a single longevity gene downstream of dietary restriction and hypoxia markedly alters behavior in

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Research summary

Modification of a single longevity gene downstream of dietary restriction and hypoxia alters behavior. The paper explores the connection between a longevity gene and behavior, which may provide insights into the biological mechanisms linking health and lifespan.

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