Transgenerational adaptation to hypoxia.

Kathleen Kim, Ariel Telger, Gautam Sarkar, Sharan Surya, M Hafiz Rothi, Michael P Meers, Simon Yuan Wang, Eric Lieberman Greer

Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA.Department of Pediatrics, HMS Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA. · pubmed

Paper

Abstract

Epigenetic inheritance alerts naïve descendants to prepare for stresses that could still be present, whereas distant descendants return to a basal state after several generations without stress. However, organisms are frequently exposed to stresses successively across generations. We found that parental hypoxia exposure increased P0 longevity, caused intergenerational lipid reduction, and elicited transgenerational fertility reduction that was dependent on generationally transmitted small RNAs. Here, we find that

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Research summary

Parental hypoxia exposure increases longevity and affects fertility across generations through small RNAs. The study explores mechanisms of transgenerational adaptation that could inform understanding of longevity and aging processes.

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