Mendelian randomization study implicates inflammaging biomarkers in retinal vasculature, cardiovascular diseases, and longevity.

Ana Villaplana-Velasco, Nicolas Perrot, Yu Hang, Michael Chong, Emanuele Trucco, Muthu R K Mookiah, Walter Nelson, Jeremy Petch, Hertzel C Gerstein, Parminder Raina, Salim Yusuf, Miguel O Bernabeu, Albert Tenesa, Konrad Rawlik, Guillaume Pare, Alexander Doney, Erola Pairo-Castineira, Marie Pigeyre

Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. · pubmed

Paper

Abstract

With the increasing proportion of elderly individuals, understanding biological mechanisms of aging is critical. Retinal vascular complexity, measured as fractal dimension (

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Research summary

The study suggests that inflammaging biomarkers are implicated in retinal vasculature and cardiovascular diseases, which may influence longevity. This research is relevant as it explores biological mechanisms of aging and their potential impact on lifespan, rather than merely addressing age-related diseases.

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