Break free from cognitive impairment: The magic of exercise-induced molecules.

Wenbo Liu, Hui Zhang, Qiuting Zeng, Wenlan Cai, Yunfeng Rui, Jie Sun

Department of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China.Department of Anesthesiology & Key Laboratory of Clinical Science and Research, Department of Anesthesiology, Zhongda, Hospital, Medical School, Southeast University, China. · pubmed

Paper

Abstract

•Exercise-induced molecules regulate cognition via trophic, immune, and metabolic pathways.•Muscle-brain crosstalk contributes to cognitive resilience in aging and neurodegeneration.•CTSB, lactate and others show dual roles-protective yet potentially pathological-depending on context.•Translational perspective: target exercise-mimetic molecules as non-pharmacological options for cognitive disorders.

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Research summary

Exercise-induced molecules can regulate cognition and contribute to cognitive resilience in aging. The paper addresses mechanisms that may help mitigate cognitive decline associated with aging, aligning with longevity research goals.

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