6-shogaol improves the cognitive and memory declines of natural aging mice by modulating butyrate-producing microbiota and intestinal barrier.
Abstract
6-Shogaol is a natural dietary phenolic extensively rich in edible and medicinal plants such as Zingiber officinale Roscoe and Brassica spp., utilized as tumor inhibitor and a promising anti-aging drug. Our previous study has revealed that 6-shogaol significantly prolonged healthy life of C. elegans. However, the interactions of 6-shogaol with the microbiota, gut and brain during natural aging process remain largely unexplored.
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Research summary
6-Shogaol improves cognitive and memory declines in aging mice by modulating gut microbiota and intestinal barrier function. The study addresses the interactions between a natural compound and the aging process, focusing on potential mechanisms that could influence longevity and age-related cognitive decline.
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